Apoe4, a particular allele of the apolipoprotein apoe, is a known risk factor. Another important gene that interacts with our diet is apolipoprotein e commonly called apoe. In her book the apo e gene diet, integrative medicine nurse practitioner pamela mcdonald explains that its important to know which type of apo e gene you have because each gene type is linked with a higher risk of particular diseases. Perfect gene diet author pamela mcdonald talks about her patient that is an apoe 44, her high cholesterol, heart disease and how pam helped her lower it with diet alone apo e gene program. Weight is a very touchy subject and when it comes to relationships, one should always tread lightly. The classic guide to understanding the opposite sex. Apoe4 is more common 2030% occurrence in africans and caucasians than in other ethnic groups. Eating the correct balance of carbohydrates, fats, and proteins for your genotype. I was very eager to read this book after hearing dr dyer speak about it and was disappointed in the inconsistencies, lack of back up in many of. The apo e gene diet focuses on the prevention and reversal of serious diseases such as.
The perfect gene diet, also known as the apoe gene diet is a genetically tailored integrative nutritional plan that focuses on eating the optimal percentages of the big three carbohydrates, fats, and proteins food groups for your specific apo e genotype. Apoe 4, a particular allele of the apolipoprotein apoe, is a known risk factor. Feb 02, 2009 pamela mcdonald author of the apo e gene diet a breakthrough in changing cholesterol, weight, heart disease and alzheimers disease using the bodys own genes. Oct 04, 2014 pam sends me messages and updates on a regular basis to remind me to stay on the path of the perfect gene diet. Infections archives perfect health diet perfect health. Apoe is transcriptionally activated by the liver x receptor an important regulator of cholesterol, fatty acid, and glucose homeostasis and peroxisome proliferatoractivated receptor. The perfect gene apoe diet white rock naturopathic. An expository email thread interruption hb is hemoglobin, which is a protein in red blood cells that carries oxygen to your bodys organs and tissues and transports carbon dioxide from your organs and tissues back to your lungs. Perfect gene diet integrative medicine consultants inc. Some studies have reported that blood lipid response to diet or obesity varies depending on apoe genotypes. Apolipoprotein e apoe polymorphism is associated with lipid levels. Perfect gene diet softcover the apo e gene online program. A breakthrough in changing cholesterol, weight, heart and alzheimers disease using the bodys own genes, describes nutritional plans for each apoe genotype. Use your bodys own apo e gene to treat high cholesterol, weight problems, heart disease, alzheimersand more.
Use your bodys own apo e gene to treat high cholesterol, weight problems, heart disease. May 24, 2018 apoe is a fascinating little gene that codes apolipoprotein e or apoe for short, a protein involved in lipid metabolism and cholesterol transport. This is a facebook page for the online group, a website created by apoe. Sign in to view your results for this health report. Case studies have shown tremendous progress with diet, exercise and lifestyle changes for slowing and even reversing symptoms. The study then tested participants dna for 3 specific gene variations and found that those using the best diet for their dna lost as much as 2 12 times more weight than those not using their best dna diet.
Apoe codes the protein apolipoprotein e or apoe, which plays a major role in how we metabolize and transport fat, cholesterol, and fatsoluble vitamins. It is setting a new standard for individualized metabolic typing and personalized diets. When it comes to alzheimers and heart disease, one of the most important genes to know about is apoe. The perfect gene diet and a journey to health wayne dyer. What in the heck is apoe and why does it reveal your. High cholesterol, apoe gene and diet gb healthwatch. Three main apoe variants exist e2, e3, and e4, and all of us carry a combination of. The perfect gene diet by pamela mcdonald post by asiagillett sat aug 30, 2014 12.
We look at your health in a totally different way, using your personal genotype to customize your diet and lifestyle choices while addressing your whole person body, mind, and spirit. Were proud to now be able to provide apoe genomic testing at white rock naturopathic for those wishing to pursue the perfect gene or apoe diet. If you want to know more to see if the ketogenic diet is going to be useful for you, ive made a free assessment for you which you can take right now because the ketogenic diet can keep your apoe4 clean and preventing it from getting dirty. John gray made that very clear in his famous book, men are from mars, women are from venus. The perfect gene diet is a healthy lifestyle program that focuses on the apo e gene, which plays a role in our risk of developing alzheimers and heart disease. Since apoe plays a critical role in the transport of cholesterol and fats to the brain, it can be hypothesized that insufficient fat and cholesterol in the brain play a critical role in the disease process.
Like all of our genes, the epigenetic expression through our diet, exercise and lifestyle ultimately determine the function. Back in the 1990s, a major susceptibility gene was discovered for alzheimers, called apoe4. Your familys ailments may be linked to a gene known as apolipoprotein e apoe, which determines how your body metabolizes certain foods. Determine your apoe status using snps rs429358 and rs7412. Associations between apolipoprotein e genotype, diet, body. It was created by pamela mcdonald, an integrative nursepractitioner and international speaker. The perfect apoe gene diet white rock naturopathic. Pamela mcdonald author of the apo e gene diet youtube. The apoe gene consists of four exons and three introns, totaling 3597 base pairs. The apoe gene fact sheet genes contain the information to make all the proteins our body needs.
This comprehensive work by nurse practitioner pamela mcdonald. If were like the 1in50 folks who have apoe4 genes from both parents, we. How your apoe genes lead to diabetes or heart disease. Apo e 3, the most common type of apo e gene, is connected to diabetes and insulin resistance. According to cardiologist suzanne steinbaum, do, author of dr. Use your bodys own apo e gene to treat high cholesterol, weight problems, heart disease, alzheimers. Dyerthis comprehensive work by nurse practitioner pamela mcdonald reveals the latest breakthrough in health and nutrition focusing on the apo e gene, which affects cholesterol levels, heart and alzheimers disease, and much. The changes will make the diet resemble more of a glutenfree vegetarian meal plan but still promote the essential qualities of the paleo diet, which can support certain healthy habits, like eating fewer processed foods and hydrogenated oils. Introduction dyslipidemia has been defined as one of the principal risk factors for the development of cardiovascular diseases cvd 1, 2. Faclm on june 26th, 2018 back in the 1990s, a major susceptibility gene was discovered for alzheimers, called apoe4. Apoe is a fascinating little gene that codes apolipoprotein e or apoe for short, a protein involved in lipid metabolism and cholesterol transport.
We know that people need different proportions of nutrients in their diet, and the author does give these. In this book it relates to you how your particular body, or genes, would best respond to certain foods and certain exercise. Apoe is produced primarily in the brain and the liver, and acts like a taxi for fats and cholesterol in our body, delivering vital nutrients that are essential to create new cell membranes including neuronal cell membranes, hormones, and much more. This comprehensive work by nurse practitioner pamela mcdonald reveals the latest breakthrough in health and nutrition focusing on the apo e. Her book is well written and offers not just a diet, but a lifestyle change it was exciting to hear about the progress being made in genetics which ive been anticipating. If we have one apoe4 gene, either from our mom or dad, like about 15 percent of the u. A low fat diet a ffects different apoe genotypes differently. Lowfat diets can help reduce the risk for these diseases.
Mice lacking apoe are susceptible to listeria monocytogenes 32 and mycobacterium tuberculosis 33. In short, testing for the presence of the apoe4 variant is the best way to understand your risk of developing alzheimers. Read the perfect gene diet use your bodys own apo e gene to treat high cholesterol, weight problems, heart disease, alzheimers. The apo e gene online program is not business as usual. In addition, the apo e gene diet takes into account the whole person physical, emotional, mental, and spiritual in creating a genesupportive environment that. Pamela mcdonald author of the apo e gene diet a breakthrough in changing cholesterol, weight, heart disease and alzheimers disease using the bodys own genes. For apoe2 the overall ldl count declines, but at the expense of increased numbers of small particle, arteriosclerosispromoting ldl, which make up the socalled undesirable pattern b. Exercising your body in ways best matched to your genotype and your health. It is the love and higher consciousness in these remarkable women who researched and wrote this book that i want to acquaint you with. Depending on what you inherited from your parents, youll carry a combination of any two apoe variants. The number of americans with alzheimers disease will reach a staggering 14 million by 2050 1. The most effective strategies for alzheimers disease and apoe. The gene, apoe, is mapped to chromosome 19 in a cluster with apolipoprotein c1 apoc1 and the apolipoprotein c2 apoc2. The book goes into great detail on basic wellness and it accounts for a large portion of the information.
Apoe is transcriptionally activated by the liver x receptor an important regulator of cholesterol, fatty acid, and glucose homeostasis and peroxisome. These publications can act as standalone diet and weight loss plans, or supplement your efforts. After listening to wayne dyer and pat mcdonald speak about the apo e gene diet, i was intrigued enough to purchase the book. There is much interest in the genes that differ between people and the impact that these differences may have on our health and risk of disease. One full year of acces to the 16week online program. Donate join the alzheimers integrative medicine foundation in providing education and research for the prevention and reversal of alzheimers disease. Pam sends me messages and updates on a regular basis to remind me to stay on the path of the perfect gene diet. Now you need to know, and be supported in implementing, the diet, exercise and lifestyle recommendations to guide you to a healthier future. The apoe gene is associated with alzheimers disease, but it cannot predict you getting it. Lipoproteins may be even more important against viruses. For 2030% of africans and caucasians with the apoe4 gene, a low fat diet can reduce risk for high cholesterol. Use your own apoe genotype to ward off diseases and get healthy.
It is a book devoted to recommendations for all the various apoe permutations with regard to diet and excercise plus some general stuff. Results showed that some participants lost weight on one type of diet, such as lowfat, while others did not. The ketogenic diet is something to seriously consider. Certain factors contribute to risk, including lifestyle, diet and genetics in particular a genetic variant known as apoe4.
We now know that imbalances to your diet, not necessarily as determined by generic dietary guidelines, but rather as determined by. High blood cholesterol is a major risk factor for cardiovascular diseases. The apo e gene diet focuses on an individuals genetic recipe, creating dietary and exercise recommendations for each of the six possible apo e genotypes. Crack the cover on these books to find motivation, insight and instruction for living a healthier life and losing weight. Everyday low prices and free delivery on eligible orders.
While the book describes the science behind the diet, the actual diet the author recommends falls far short of being truly healthy. Analysis of gene diet and gene obesity interactions did not confirm that the effects of diet and obesity on tc and ldlc level significantly depended on apoe genotype. In addition, testing for apoe and interpreting the results is the first step to allow your doctor to create a tailored program for you to help prevent the onset of alzheimers disease if you already have it. The genetic information and the specific diet for your genes. This gene plays a key role in our bodys internal environment and influences the development of chronic disease, especially. Apr 25, 2017 the apoe gene is associated with alzheimers disease, but it cannot predict you getting it. This article attempts to explain the link between diet, the apoe4 gene and alzheimers in plain english. Apoe4 carriers are prone to high cholesterol and alzheimers disease. Use your bodys own apo e gene to treat high cholesterol, weight problems. If the gene for apoe, a protein found in idl which upregulates vldl levels, is knocked out, mice become more susceptible to infection, so it appears that apoe also has immune functions 28. We encourage you to start by becoming informed about the basics of apoe.